The next step forward in our understanding of tolerance, very much involves TB collaboration and the role of thymus derive cells on the one hand, and bone marrow's derive cells on the other, T-cells and B-cells. And, I'd just like to back over what we had touched on so far, which is that there is no doubt that the end of the 1960s, and in particular 1969, was the decisive- you know, when TB co-operation was discovered and worked out, mostly worked out, that the elements which were needed for that were the discovery that T-cells, a separate population of cells, comes out of the thymus called T-cells, and that's the work of Jacques Miller and to an extent which I'm not quite clear about, contemporary work done by Bob Goode and his colleagues in America. One mainly on mice and the other mainly on humans, but some overlap.