Everyone jumping on to the bandwagon

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IA became the new nomenclature

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Everyone jumping on to the bandwagon

Jan Klein Scientist

	Views	Duration
61. Everyone jumping on to the bandwagon	25	01:35
62. IA became the new nomenclature	19	05:47
63. Working in an increasingly competitive field	19	05:22
64. Calling the two antigens class I and class II	28	03:40
65. Class I and class II nomenclature eventually prevailed	28	02:33
66. Adoption of the term major histocompatability complex	28	01:49
67. Differing concepts of the H2 system	24	05:11
68. Collaboration and friendship with Fritz Bach	63	02:59
69. Dual recognition appeared as a bolt out of the blue	27	05:10
70. How does the immune response function?	21	02:43

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Two months later in September 1973, Chella David who was working with Shreffler... was the main person involved in the search for these antibodies. So Chella and Don and all the co-workers published a paper in Proceedings of the National Academy of Sciences, United States [of America], describing in a different combination the antigens that were also controlled by the origin and they called them LNA for Lymph Node-associated Antigens. So, within a span of two months the product of the IR region was identified by our two groups and then a few months later one paper after the other was beginning to appear when other groups were identifying also similar products. It just illustrates how hot the area was, that everybody jumped immediately on the bandwagon and the whole bandwagon began to roll and it would not stop until the whole area is exhausted.

Born in 1936, Jan Klein is a Czech-American immunologist who co-founded the modern science of immunogenetics – key to understanding illness and disease. He is the author or co-author of over 560 scientific publications and of seven books including 'Where Do We Come From?' which examines the molecular evolution of humans. He graduated from the Charles University at Prague in 1955, and received his MS in Botany from the same school in 1958. From 1977 to his retirement in 2004, he was the Director of the Max Planck Institute for Biology at Tübingen, Germany.

Title: Everyone jumping on to the bandwagon

Listeners: Colm O'hUigin

Colm O'hUigin is a senior staff scientist at the US National Cancer Institute. He received his BA, MSc and PhD at the Genetics Department of Trinity College, Dublin where he later returned as a lecturer. He has held appointments at the Center for Population and Demographic Genetics, UT Houston, and at the University of Cambridge. As an EMBO fellow, he moved in 1990 to the Max Planck Institute for Biology in Tübingen, Germany to work with Jan Klein and lead a research group studying the evolutionary origins of immune molecules, of teeth, trypanosomes and of species.

Tags: LNA, Lymph Node-associated Antigen, Proceedings of the National Academy of Sciences of the United States of America, Chella David, Donald C Shreffler

Duration: 1 minute, 35 seconds

Date story recorded: August 2005

Date story went live: 24 January 2008