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Researching ribose metabolism
Howard Hiatt
Physician
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Views | Duration | |
|---|---|---|---|
| 1. Talking to Web of Stories | 762 | 02:01 | |
| 2. Family peregrination ends in the USA | 347 | 03:31 | |
| 3. Why I became a doctor | 320 | 02:02 | |
| 4. Accepted by Harvard to major in English | 161 | 02:35 | |
| 5. My early medical career | 143 | 04:15 | |
| 6. My wife: the most important person in my life | 274 | 01:40 | |
| 7. Discovering the beauties of science | 113 | 03:28 | |
| 8. Sidewalk seminars | 69 | 01:33 | |
| 9. Crash course in oncology | 113 | 03:00 | |
| 10. Researching ribose metabolism | 67 | 02:03 |
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One of the questions that I asked when I worked with Bernie was whether the pentose phosphate pathway was the source of the ribose in RNA, the five carbon sugar in RNA and ribonucleic acid. And I began to examine that question, and in my lab in Boston sought to see whether, in fact, there were differences in... in the way RNA was synthesized in tumor cells as compared with normal cells. I did a series of studies of ribose metabolism using the background that I had acquired with Bernie, and wrote several papers in the biochemical literature on this subject, organized the clinical program and within... within two or three years of my return, Bernie Horecker, with whom I continued to do a fair amount of collaborative work, said to me, 'You know, if you really want to understand the neoplastic process, the cancer... how cancer... how the cancer behaves, you really should get to... some background in this new field of molecular biology'. Bernie had just spent a year at the Pasteur Institute in Paris which was, at that time, the center of the field now called molecular biology, and Bernie urged that I consider taking leave and going there.
Born in 1925, American Howard Hiatt set up one of the first medical oncology research and training units in the US and has headed up some of America's most prestigious medical institutions. Hiatt attended Harvard College and received his MD from the Harvard Medical School in 1948. He was a member of the team at the Pasteur Institute, Paris, that first identified and described mRNA, and he was among the first to demonstrate mRNA in mammalian cells. From 1991 to 1997, he was Secretary of the American Academy of Arts and Sciences, where he began and directs the Academy's Initiatives For Children program. He is also committed to helping disadvantaged people access decent health care.
Title: Researching ribose metabolism
Listeners: Milton C. Weinstein
Milton C. Weinstein, Ph.D., is the Henry J. Kaiser Professor of Health Policy and Management at the Harvard School of Public Health and Professor of Medicine at the Harvard Medical School. At the Harvard School of Public Health he is Academic Director of the Program in Health Decision Science, and Director of the Program on Economic Evaluation of Medical Technology . He is best known for his research on cost-effectiveness of medical practices and for developing methods of economic evaluation and decision analysis in health care. He is a co-developer of the CEPAC (Cost-Effectiveness of Preventing AIDS Complications) computer simulation model, and has conducted studies on prevention and treatment of HIV infections. He is the co-developer of the Coronary Heart Disease Policy Model, which has been used to evaluate the cost-effectiveness of cardiovascular prevention and treatment. He is an author of four books: Decision Making in Health and Medicine: Integrating Evidence and Values; Cost-Effectiveness in Health and Medicine,the report of the Panel of Cost Effectiveness in Health and Medicine; Clinical Decision Analysis; and Hypertension: A Policy Perspective.He has also published more than 200 papers in peer-reviewed medical, public health, and economics journals. He is an elected member of the Institute of Medicine of the National Academy of Sciences, and a recipient of the Award for Career Achievement from the Society for Medical Decision Making. Dr. Weinstein received his A.B. and A.M. in Applied Mathematics (1970), his M.P.P. (1972), and his Ph.D. in Public Policy (1973) from Harvard University.
Tags: Pasteur Institute, Bernard Horecker
Duration: 2 minutes, 3 seconds
Date story recorded: September 2006
Date story went live: 24 January 2008
