I have been kind of living with this phenomenon of cross-suppression for years and years and years, and finding out more about the phenomena but not really understanding the underlying mechanism, but at that time in 1990 when I moved or was planning to move, the importance of cytokines had just emerged and in particular, the suppressive genes, which I had been studying, looked- began to look very much like regulation through cytokines, what is now called TH1/TH2 balance. So TH1/TH2, the division of T-cells like that had been discovered by a Canadian working, if I remember correctly, in the United States at the time, but I thought well that was likely to be very important to the disease, and it would also explain this cross-activation you would have. One of the alleles that would turn on a TH2 response which would suppress the response to the TH1 allele and that might be useful as a model for the treatment of the disease. So, I was very uncertain about whether I wanted to move to Germany or not. I dithered like anything, I said no to begin with, and then two persuasive gentlemen arrived at University College and I had by that time more or less decided that I would move. I thought it was time that the ICRF unit should close down. Mark Feldman, who was the other strong scientist there, had moved away, Hans Stauss was ready to move to a more clinical environment. Peter Beverley, who had done terrific work on T-cell subsets in man, had already moved to a semi-autonomous unit in another part of University College. So it was getting thin on the ground and I detected considerable reluctance in ICRF- they never said they were going to close you down but I think they would have done before very long unless something pretty drastic had been done. So I moved, I decided to move.