Is the network dead? No, I doubt it. I think that there is- are network effects, particularly in very young mice, in baby mice, which have been quite carefully described and where immunoglobulins have been put in, and they constantly put in immunoglobulin- become evident- and somehow the immune system recognises that. Whether it matters- if network- if the idiotypic network matters at all, I suspect that it matters mainly or perhaps exclusively in establishment of the early repertoire, the range of antibodies which the body makes, the immune system makes, and it's fairly unimportant in the context of disease, unless the structure of the repertoire is impacting seriously on disease susceptibility, which it may do. I wouldn't say more than that.