Francis Peyton Rous' review of our paper

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Our article is published in Experimental Cell Research

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Francis Peyton Rous' review of our paper

Leonard Hayflick Scientist

	Views	Duration
101. Theodore Puck	49	01:50
102. Theodore Puck confirms my observations	43	04:04
103. Demonstrating that our cultured cells were normal	49	02:23
104. Fulfilling Koch's postulates	54	03:16
105. Ageing as an interpretation for the non-proliferation of cells in...	62	02:07
106. Our paper in the Journal of Experimental Medicine	48	03:59
107. The Journal of Experimental Medicine rejects our paper	58	01:02
108. Francis Peyton Rous' review of our paper	77	01:59
109. Our article is published in Experimental Cell Research	67	01:23
110. Dangers surrounding the use of cultured monkey kidney cells	72	02:38

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The first statement was that – and I think I can quote this pretty accurately – as anyone who has worked with cell culture will know, that cells cultured under the proper milieu in vitro will replicate indefinitely, which was precisely the dogma that we had thought we had torpedoed.

The next paragraph said: 'The suggestion that these events have anything to do with ageing is notably rash', end quote. The letter was signed by Peyton Rous, R O U S. Peyton Rous received the Nobel prize two years after our paper was rejected over his signature. He was well known and a well respected scientist. He not only discovered the Rous sarcoma virus, a virus of chickens that produces tumours, he also was the first to describe trypsin as an enzyme useful in cell culture and his description of trypsin lay unrecognised in the literature for about 15 years before it finally became rediscovered as a useful enzyme.

Well, that was a shock. Paul and I were pretty upset. The paper was lengthy and it described things in great detail and here we were faced with this rejection.

Leonard Hayflick (b. 1928), the recipient of several research prizes and awards, including the 1991 Sandoz Prize for Gerontological Research, is known for his research in cell biology, virus vaccine development, and mycoplasmology. He also has studied the ageing process for more than thirty years. Hayflick is known for discovering that human cells divide for a limited number of times in vitro (refuting the contention by Alexis Carrel that normal body cells are immortal), which is known as the Hayflick limit, as well as developing the first normal human diploid cell strains for studies on human ageing and for research use throughout the world. He also made the first oral polio vaccine produced in a continuously propogated cell strain - work which contributed to significant virus vaccine development.

Title: Francis Peyton Rous' review of our paper

Listeners: Christopher Sykes

Christopher Sykes is a London-based television producer and director who has made a number of documentary films for BBC TV, Channel 4 and PBS.

Tags: Peyton Rous

Duration: 1 minute, 59 seconds

Date story recorded: July 2011

Date story went live: 08 August 2012