Very lucky when we were working with cyclic AMP that Steve Siegelbaum whom I'd met very briefly, because he was working in Paris when I visited there one time, was recruited to Columbia in the pharmacology department, and we had talked a little bit about working on Aplysia when we met in Paris, and he worked in Aplysia, and he isolated channels using patch clamp technique which was a very, you know, modern technique at that time. Very few people had mastered it. He had spent some time with Bert Sakmann and learned how to do it, and isolated a potassium channel modulated by serotonin and cyclic AMP. Cyclic AMP stimulated by serotonin closed that potassium channel, and that was one of the contributing factors to the broadening of the action potential with sensitization which led to increased calcium influx and enhanced transmitter release.
And we called that the S channel because it was named after Steve, and it was modulated by serotonin.
Steve has become one of my closest friends at Columbia, spectacular scientist, gone on to do a number of wonderful things since then, including recently showing that the area CA2 in the hippocampus is involved in social behavior, may be impaired specifically in schizophrenia, is now chairman of the neuroscience department which he took over from John Koester, I think you know who John Koester is. And like John Koester has done a fabulous job leading the department.