Another remarkable lesson that emerged was, don't worry, if you can think of something dangerous, nature's probably done it. And one of the most dangerous things we could think of, because the idea was think of something that's practically dangerous and then see how you would deal with it. So I surmised of taking cholera toxin and putting it in E. coli (Escherichia coli) so that delivers the toxin to the right place, in a vector that can infect other bacteria, and that I considered a dangerous experiment, and then showed how one would cope with this. Well, it's been done befo... it's been done. It's called Shiga toxin. This is in fact the same kind of toxin as cholera toxin, it exists in a bacteriophage related to the common bacteriophage that we use in our laboratories – Llambda. This bacteriophage infects a Shigella bacterium, which is quite closely related to the common E. coli. And that's how nature has done it before. And of course always has priority over us. Well, having spe... I spent an inordinate amount of my time on this. And I think it was basically required in the sense that if people who were sensible had not done, then had not participated in this process we would have been left in some of the difficulties say, that they have in Germany today where it's extreme... it's impossible to do genetic experimentation. Or in parts of Japan as well, where it's impossible to do this kind of experimentation.