One of the problems in evolution and development is the evolutionary origin of larval forms. If you take... look, a key model system for development is the fruit fly, Drosophila. So the egg of the fruit fly thing and it forms a little larva. And then the larva goes through... grows a little bit, and then suddenly it undergoes a metamorphosis, and out pops a fly. How is it possible for this larva to turn into a fly? All right, we know that hormones. Well, I must confess that I have quite a simple answer to this problem. I’ve never seen anybody quote it, once again, and the way to think about it is that really what has happened in development is that at a certain stage in normal development in the original animal, it was discovered the following. I think the best way to think about it is in relation to frogs. So think about the following: it’s about the origin of the tadpole. And the origin of the tadpole and the frog is best understood... is that in the normal development of the frog, it goes through a phase where it really is... looks like a sort of slightly elongated form of the embryo. And what happened in evolution is there were changes, it... it stopped developing at this stage and it evolved into a tadpole, which then could swim away, get food, get bigger, and then all that metamorphosis is, is going back into the normal developmental programme. So it’s just a side track from the normal developmental programme. It goes off somewhere and where metamorphosis is, it’s going back to the... it recapitulates its original programme.