Worldwide production of vaccines using the WI-38 cell strain

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Establishing criteria for the karyology of our cell cultures

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Worldwide production of vaccines using the WI-38 cell strain

Leonard Hayflick Scientist

		Views	Duration
121. Frank Perkins		56	02:37
122. Human adult cell replication lower than fetal cell replication		67	01:52
123. Nathan Shock		62	02:16
124. Replacing WI-25 with WI-26		65	02:48
125. Searching for healthy female fetal tissue		181	04:29
126. Laying down the first standards for vaccine production		63	05:31
127. The global distribution of WI-38		222	00:56
128. The Hayflick limit	2	220	02:06
129. Drago Ikić promotes the use of human cell culture		72	02:11
130. Worldwide production of vaccines using the WI-38 cell strain		134	01:40

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The proceedings were subsequently published in book form and it contained an array of papers, including many from the laboratory of Drago Ikić in which he described the preparation of vaccines against several virus diseases; not only polio. So, it sets the stage now for worldwide production of vaccines on WI-38 and eventually other cell populations.

The other important cell populations I may have mentioned earlier, but I'll now link it to these events was MRC-5. That strain was developed by Frank Perkins seven years after I published on WI-38, and it is identical to WI-38 in all respects other than it, of course, came from a different embryo. Several countries, but Frank was first, wanted their own strain for purposes of national pride, which was... is understandable, of course. They're very easy to make, following my recipe. And MRC-5 was used in later years for polio vaccine production and other vaccines, and it's used even to this day along with WI-38. MRC stands, of course, for... for Medical Research Council in Hampstead. There... and Frank laid down, of course, many hundreds of ampoules for this subsequent distribution.

Leonard Hayflick (b. 1928), the recipient of several research prizes and awards, including the 1991 Sandoz Prize for Gerontological Research, is known for his research in cell biology, virus vaccine development, and mycoplasmology. He also has studied the ageing process for more than thirty years. Hayflick is known for discovering that human cells divide for a limited number of times in vitro (refuting the contention by Alexis Carrel that normal body cells are immortal), which is known as the Hayflick limit, as well as developing the first normal human diploid cell strains for studies on human ageing and for research use throughout the world. He also made the first oral polio vaccine produced in a continuously propogated cell strain - work which contributed to significant virus vaccine development.

Title: Worldwide production of vaccines using the WI-38 cell strain

Listeners: Christopher Sykes

Christopher Sykes is a London-based television producer and director who has made a number of documentary films for BBC TV, Channel 4 and PBS.

Tags: Drago Ikić, Frank Perkins

Duration: 1 minute, 40 seconds

Date story recorded: July 2011

Date story went live: 08 August 2012